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Findings

What does this study add?

  • Both cephalic and extra-cephalic allodynia started one week after MF-induced TBI, persisting for at least nine weeks.
  • For CHI, a transient cephalic hypersensitivity developed between day one and day five after injury and a long-lasting sensitization to non-noxious migraine triggers in both cephalic and extra-cephalic.
  • Multiple injuries over three days were more deleterious than single of multiple injuries in one day.