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Background

What do we already know about this topic?

  • PTH is highly prevalent in active and retired military personnel, as well as in sport athletes.
  • 70–90% of TBIs are mild.
  • There is a 2–5 times greater risk of a new TBI after the first one.
  • Patients experience a resolution of acute symptoms within 12 weeks.
  • TBI are heterogeneous with a variable clinical presentation, but more than half of patients suffer from PTH associated with severe tactile allodynia.
  • Mice can be primed by a closed head impact-induced mTBI event, sensitizing them to subsequent migraine triggers.

How was this study conducted?

  • Direct comparison of hypersensitivity induced by two different mice models of mild TBI over 4-9 weeks.
  • A multifactorial injury model (MF) using an over-pressure (30 psi) air blast and a closed head impact model (CHI) dropping a 30g weight onto the intact skull were used.
  • Von Frey filaments were used to stimulate the periorbital facial and plantar paw areas.
  • Single and multiple (three times in one day and three times over three days) injuries were tested.
  • The hypersensitivity response to migraine triggers CGRP and sodium nitroprusside (SNP) were evaluated over 13 weeks.