TBI models for PTH treatment evaluation

Key messages

• Post-traumatic headache (PTH) following mild traumatic brain injury (mTBI) is debilitating and difficult to diagnose, often presenting the same symptoms as migraine.
• Symptoms can be studied in mice, but further research is required in animal models to develop new effective PTH treatments.
• Animal models suggest multifactorial injury induces a persistant generalized phenotype while a closed-head impact injury induces a transient localized phenotype.
• The results of the study support a causative role of calcitonin gene-related peptide (CGRP) in PTH and potential use of CGRP-targeting drugs for the treatment of PTH in clinical practice.