× Key messages Background From RISE… Conclusions Expert commentary
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Conclusions

  • Youth with IGT/T2D are more insulin resistant, have higher insulin secretion, and lower insulin clearance, more rapid beta-cell deterioration, and poorer response to interventions vs. adults.
  • Insulin sensitivity and first phase beta-cell responses are predictors of glycemia deterioration in adults.
  • Glycemia and all beta-cell responses measures are predictors of glycemia deterioration in youth.
  • Glucagon does not explain differences in beta-cell function in youth vs. adults.
  • Gastric banding increased insulin sensitivity and clearance, preserved beta-cell function, and improved glycemia for over 2 years in adults.