Background

What do we already know about this topic?

• The increase in the prevalence of obesity has contributed to the increased incidence of prediabetes and type 2 diabetes mellitus (T2D) among youth and adults.
• Progressive decline in beta-cell function is now well recognized in children and adults to be pivotal in the progression from normal to abnormal glucose tolerance.
• Given the increased recognition of the critical role of the beta-cell in the pathogenesis of T2D, efforts have begun to shift to prevention of the loss of insulin secretion among individuals at high risk for T2D or early stages of the disease.