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How does this study impact clinical practice?

  • Cerebellar CGRP, especially in the fastigial nucleus, may contribute to some migraine-like behaviors such as light aversion, anxiety, and decreased locomotion.
  • While further studies are needed to determine the contributions of cerebellar CGRP to light aversion, there are connections between the fastigial nucleus and the posterior thalamic area, which are implicated in photophobia.