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What does this study add?

  • RNAs for both CGRP and its receptor subunits were detected in the cerebellum of C57BL/6 mice.
  • CGRP immunoreactivity was detected in PCs and deep cerebellar nuclei.
  • EYFP was present in fastigial nucleus neurons after injection of AAV-EF1a-DIO-EYFP into calca-cre mice but wasn’t detected in PCs, which suggests that PCs accumulate, but do not produce CGRP.
  • Injection of CGRP to the fastigial nucleus induced light aversion, anxiety, and allodynia, while delivery to the vermis V induced anxiety and a trend towards light aversion.
  • Phenotypes began to present from different time points following injection of CGRP into vermis V and fastigial nucleus, suggesting that light aversion, as well as anxiety, was present.
  • Preliminary data showed that CGRP injection to the fastigial nucleus of L7/hRAMP1 mice and control littermates induced comparable light aversion and anxiety, suggesting that RAMP1 in PCs is not rate-limiting for those CGRP actions.
  • CGRP injection into crus I showed a trend to impair timing.