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Background

What do we already know about this topic?

  • Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and gut motility.
  • GLP-1 receptor agonists (GLP-1RA) have been developed for the treatment of diabetes and obesity.
  • Detection of the GLP-1 receptor in multiple cell types is challenging due to low levels of expression and technical validation of reagents.
  • Originally described as an incretin hormone, research has broadened the actions of GLP-1 to encompass activity within the nervous system, gut, kidney, pancreas, heart, and immune system.1-3