What does this study add?

• Patients with MwoA who developed CA (MwoA dCA) over time, had significantly reduced functional connectivity of the main cognitive networks, when compared with patients with MwoA who did not develop CA and the healthy control group.
• Within the DMN, the reduced intrinsic posterior cingulate cortex/precuneus connectivity in patients with MwoA dCA could subtend abnormal inputs integration, from different sensory modalities, allowing the development of CA.
• Within the CEN, reduced anterior cingulate cortex and middle frontal gyrus functional connectivity in MwoA dCA patients may represent the neuronal substrate of subclinical impairment of complex executive functions, making these patients more prone to migraine chronification. In addition, decreased anterior cingulate cortex-functional connectivity was significantly associated with CA development.
• Significant microstructural changes in the corpus callosum were observed in patients with MwoA dCA.
• There were no significant correlations between the functional and microstructural changes, and the clinical and neuropsychological parameters.