Cognitive network changes are associated with cutaneous allodynia

Key messages

• Two‐thirds of patients with migraine without aura (MwoA) experience ictal cutaneous allodynia (CA).
• CA is a clinical sign of central nociceptive pathway sensitisation and an independent predictor for migraine chronification.
• Abnormalities in the main cognitive networks (the default mode network [DMN] and the central executive network [CEN]) functional connectivity, and microstructural changes in the corpus callosum, could represent a prognostic imaging biomarker to identify migraine patients prone to experiencing CA and chronic migraine.