Findings

What does this study add?

• Stress-induced transient allodynia resolved by day 14. 
• Inhalational umbellulone reinstated allodynia only in animals previously primed with stress.
• Treatment with PAR-2 mAb before restraint stress priming, did not prevent stress-induced allodynia or the stress-induced priming that was revealed by umbellulone exposure.
• In contrast, administration of the PAR-2 mAb before the umbellulone exposure in animals previously primed with stress prevented tactile allodynia.