Role of PAR-2 Receptors in Migraine

Key messages

• A novel, injury-free, preclinical model of migraine demonstrated chronic stress induced transient allodynia and a persistent state of “latent sensitization” when exposed to umbellulone.
• Blockade of PAR-2 receptors prevented umbellulone-induced allodynia in stress-primed animals.
• PAR2 is an important contributor to migraine etiology and targeting PAR-2 receptors may represent a novel strategy to prevent migraine.