Role of PAR-2 Receptors in Migraine
Key messages
- A novel, injury-free, preclinical model of migraine demonstrated chronic stress induced transient allodynia and a persistent state of “latent sensitization” when exposed to umbellulone.
- Blockade of PAR-2 receptors prevented umbellulone-induced allodynia in stress-primed animals.
- PAR2 is an important contributor to migraine etiology and targeting PAR-2 receptors may represent a novel strategy to prevent migraine.