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What do we already know about this topic?

  • In clinical trials, CGRP antagonists demonstrated a reduction in headache frequency comparable to other preventives and were well tolerated.
  • The real-world effectiveness of CGRP antagonists is unknown.

How was this study conducted?

  • A retrospective cohort study of adult patients (N=336) with a diagnosis of migraine treated with CGRP-antagonists at Cleveland Clinic between May 18, 2018 and December 31, 2018, who had minimum 3 month follow-up.
  • Data collected included age, gender, ethnicity, marital status, pre and post-treatment Headache Impact Test (HIT-6) scores and number of prior failed preventives.
  • Descriptive statistics were calculated for the sample stratified by improvement group; marginal/no improvement, 50%, 75% and 100%.