What do we already know about this topic?

• In clinical trials, CGRP antagonists demonstrated a reduction in headache frequency comparable to other preventives and were well tolerated.
• The real-world effectiveness of CGRP antagonists is unknown.

How was this study conducted?

• A retrospective cohort study of adult patients (N=336) with a diagnosis of migraine treated with CGRP-antagonists at Cleveland Clinic between May 18, 2018 and December 31, 2018, who had minimum 3 month follow-up.
• Data collected included age, gender, ethnicity, marital status, pre and post-treatment Headache Impact Test (HIT-6) scores and number of prior failed preventives.
• Descriptive statistics were calculated for the sample stratified by improvement group; marginal/no improvement, 50%, 75% and 100%.