What do we already know about this topic?

• Migraine and dementia are the most prevalent neurological disorders and leading causes of disability in the world.
• Life expectancy is increasing worldwide, and consequently, so are age-related diseases such as dementia, representing a challenge for health and social care. ^1,2,3,4,5
• Previous studies have reported an association between migraine and dementia risk, but they have not differentiated between migraine with or without aura, and have been limited to subtypes of dementia. ^6–13

How was this study conducted?

• A Danish population-based longitudinal cohort study (N=62,578) using national register data on individuals born 1935–1956 diagnosed with migraine midlife (31–58 years) between 1988–2017.
• Individuals registered with migraine before turning 59 years old (n=18,135) were matched (1:5) on sex and birthdate with individuals without migraine (n=1,378,346).
• Outcome measures were dementia diagnosis or redemption of dementia medications after the age of 60.