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Impact of Galcanezumab on Total Pain Burden: Findings from Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies in Patients with Episodic or Chronic Migraine

book_2 Source: AHSAM 2020 - Poster session Published on September 11, 2020
calendar_today Published on Medfyle: August 2020
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Key messages

  • This post hoc analysis of 3 randomized double-blind, placebo-controlled studies in patients with episodic migraine (EM; 2 pooled 6-month studies)or chronic migraine (CM; one 3-month study) assessed the impact of galcanezumab 120 mg once-monthly injection on total pain burden
  • Greater reduction in total pain burden was seen in patients treated with galcanezumab 120 mg once-monthly-injection relative to placebo for both EM and CM; treatment with galcanezumab 120 mg provided a further reduction in total pain burden in addition to the reduction explained by the decrease in monthly migraine headache days.
  • Total pain burden was numerically more strongly correlated with MSQ and MIDAS than the individual components themselves, which suggests this may provide a more holistic approach that is more closely related to subjective patient outcomes.
Presenting Author
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Jessica Ailani, MD
Director Medstar Georgetown Headache Center, Associate Professor Neurology
Department of Neurology, Georgetown University Hospital
Washington D.C., District of Columbia

Jessica Ailani is a Professor of Clinical Neurology, Director of the Georgetown Headache Center, and Vice Co-Chair of Strategic planning Neurology at MedStar Georgetown University Hospital in Washington, DC. Dr. Ailani is a fellow of the American headache society and the American Academy of Neurology. She holds a position on the board as a member at large, is the co-chair of the Practice management group and is on the scientific and Scottsdale program planning committees . She is section editor of Unusual Headache Syndromes for Current Pain and Headache Reports and a reviewer for several professional journals. Dr. Ailani has presented nationally on topics surrounding headache medicine.