Endocrinology
| T2D
Endocrinology
T2D
Effects of Acute Hyperglycemia on Monocytes in Type 2 Diabetes
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Source:
ENDO Online 2020 - Poster session
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Published on Medfyle:
July 2020
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4
min
This Medfyle was published more than two years ago. More recent Medfyle on this topic may now be available.
Key messages
- Acute hyperglycemia in vitro induces monocyte cholesterol uptake promoting foam cell formation
- This is a potential mechanism by which acute hyperglycemia potentiates CVD by activating monocytes and enhancing its cholesterol content.
- We postulate that these monocytes loaded with cholesterol are then capable of carrying this cholesterol to plaques and contribute to nascent plaque formation.
Presenting Author
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Rong Mei Zhang, MD
Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St. Louis
Rong Mei Zhang joined Washington University as an Endocrinology fellow in 2017 when she joined the lab of Carlos Bernal-Mizrachi to study the effect of acute hyperglycemia on monocyte cholesterol metabolism. She has recently joined the Endocrinology division as a faculty member to continue her research interests studying the role of inflammation in diabetic complications.
