| Nutrition

Consuming High-Fructose Corn Syrup or Sucrose-Sweetened Beverages Increases Hepatic Lipid Content and Decreases Insulin Sensitivity in Young Adults

book_2 Source: ADA 2020 - Poster session
calendar_today Published on Medfyle: July 2020
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This Medfyle was published more than two years ago. More recent Medfyle on this topic may now be available.

Key messages

  • Epidemiological research has linked sugar consumption to the development and progression of non-alcoholic fatty liver disease and Type 2 Diabetes.
  • Our objective was to compare the consumption of HFCS or sucrose-sweetened beverages (SB) at 25% of energy requirement on hepatic lipid content and insulin sensitivity in young adults. 
  • Hepatic lipid content significantly increased during consumption of HFCS- and sucrose-SB compared with baseline levels and compared with aspartame-SB. Insulin sensitivity indexes were significantly decreased by consumption of HFCS- and sucrose-SB compared with aspartame-SB. 
  • These data are important for shaping public health policy, dietary recommendations as well as consumer choices for the prevention and treatment of non-alcoholic fatty liver disease and Type 2 Diabetes. 
Presenting Author
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Desiree Sigala, PhD
University of California Davis, USA


My interest in nutrition and human health was inspired by witnessing diet-related health disparities in my Hispanic community in Central California and being diagnosed with Type 1 Diabetes at the age of 7. I am currently a postdoctoral scholar examining the metabolic effects of consuming sugar-sweetened beverages in young adults as well as studying policy and environmental interventions to prevent chronic disease and reduce health disparities.