| Type 1 diabetes
Type 1 diabetes

Association of High-Affinity Autoantibodies with High-Risk HLA Haplotypes

book_2 Source: ADA 2020 - Poster session
calendar_today Published on Medfyle: July 2020
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This Medfyle was published more than two years ago. More recent Medfyle on this topic may now be available.

Key messages

  • ECL assays are high affinity autoantibody tests that are more specific than traditionally used RBA assays for the prediction of type 1 diabetes in natural history studies.
  • We analyzed RBA and ECL positivitiy with HLA genotypes and haplotypes in 603 TrialNet subjects 
  • ECL and RBA GAD autoantibody positivity is associated with both HLA DR3 and HLA DR4 haplotypes.
  • Only ECL-IAA (but not RBA-IAA) positivity and levels are associated with the HLA-DR4 haplotype
Presenting Author
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Taylor M. Triolo, MD 
Barbara Davis Center for Diabetes, University of Colorado School of Medicine

Assistant professor of pediatric endocrinology at the Barbara Davis Center for Diabetes in Aurora, CO, Taylor Triolo is interested in characterizing heterogeneity of type 1 diabetes.