Proposed CPM evaluation method in chronic migraine.

Key messages

• Dysfunctional endogenous analgesia has been reported in various chronic pain conditions and is  of interest in migraine research.
• Scientists have shown altered CPM in patients with migraine, but there is a lack of standardized CPM methodology.
• A recommended protocol for testing CPM has recently become available.
• Further research is required to determine if abnormalities in CPM are associated with migraine chronicity, if CPM changes with migraine therapeutics and if CPM predicts the therapeutic response to treatments.