Conclusions
- The presence of microsatellites, as defined in the 8th edition of AJCC, negatively influences melanoma-specific and disease-free survival, and increases the likelihood of sentinel lymph node positivity and loco-regional recurrence.2
- Increased distance of microsatellite from primary tumor conveys worse prognosis, but neither the size nor number of microsatellites has prognostic value.2
- Primary cilia can be used to differentiate acral melanoma.3
- miR-146 and miR-21 correlate with thickness in superficial spreading melanoma.4