Functional connectivity brain alterations during migraine attack

Key messages

• Understanding the possible changes in brain function during the different phases of the migraine attack is essential to developing disease biomarkers and advancing therapeutics.
• The subcortical regions such as the hypothalamus, thalmus and basal ganglia are involved during the early phases of migraine.
• Functional reorganization of the brain networks occurs between the subcortical and cortical areas which fluctuate during different phases of a migraine attack and lead to corresponding symptoms.
• This knowledge could lead to the development of disease and treatment biomarkers in the future to improving patient outcomes and prognosis.