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Findings

What does this study add?

  • Out of a total of 61,917,780 patients in Explorys, 4,882,710 had T2D, and 182,220 patients in the database had hypoglycemic episodes.
  • Patients were divided into 2 groups according to the number of hypoglycemic episodes per year (controls, 1-5, 158,410; cases, >5, 40,810).
  • Patients with >5 hypoglycemic episodes in 1 year (cases) had a higher incident risk of overall CV adverse events when compared to controls (OR: 1.61, 95% CI: 1.558, 1.663). 
  • Cases had more CV events (OR 1.61), cardiac arrythmias (OR 1.65), CVA (OR 1.38), and MI compared to controls (OR 1.43).
  • Cases who were elderly (age ≥65 years) had an incidence of 36% of having a CV event compared to 25% in age-matched controls.