What do we already know about this topic?

• Hypoglycemia has been linked to increased cardiovascular (CV) events.
• However, there is limited data about the relationship between the frequency of hypoglycemic episodes and CV outcomes.

How was this study conducted?

• This study evaluated the association of frequent hypoglycemic episodes (>5/year) with incident CV events in adults with type 2 diabetes (T2D).
• A national database (IBM Explorys Solutions, IBM, Inc.) for adults with T2D who had >5 hypoglycemic episodes (cases) vs. 1 to 5 hypoglycemic episodes (controls) in one year was queried.
• Primary outcomes were overall CV adverse events, acute myocardial infarction (MI), cerebrovascular accidents (CVA) and cardiac arrhythmias.